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7 min readUpdated July 2026

Mounjaro vs Wegovy vs Saxenda: how the weight-loss injections compare

The three main weight-loss injections work in related but different ways, are dosed differently, and vary in what clinical trials have shown. Here's how they compare.

How they work

All three are injections that act on gut hormone pathways to reduce appetite. Wegovy (semaglutide) and Saxenda (liraglutide) are GLP-1 receptor agonists. Mounjaro (tirzepatide) acts on two pathways (GIP as well as GLP-1). An oral GLP-1 option (a tablet) is also emerging. Which is suitable depends on your circumstances and is a decision for your prescriber.

Dosing

Mounjaro and Wegovy are weekly injections; Saxenda is a daily injection. All are started at a low dose and increased gradually over weeks (titration) to reduce side effects, which is part of why the monthly price rises as your dose goes up.

How they differ

These are different medicines with different active ingredients, dosing schedules and licensed uses. We do not publish outcome figures or compare how well they work — that is a clinical judgement. A registered prescriber will discuss the evidence for each option with you and decide what is appropriate.

Cost and availability

Prices vary by provider and dose (see our comparison), and supply can fluctuate — Wegovy and Mounjaro have both had periods of limited availability, and Saxenda is increasingly supplied as a generic. It's worth comparing current prices and checking stock before you commit, and re-checking over time as prices move.

Considering weight-loss medication? Before paying privately, our 60-second NHS eligibility check shows whether an NHS route could be open to you — it runs entirely on your device.

Frequently asked

Which weight-loss injection should I choose?
That is a clinical decision for a registered prescriber, based on your health history, other medicines and how you tolerate treatment. We do not rank medicines by effectiveness. What we can help with is comparing what UK providers charge and what is included.
Is a generic version as good as the branded one?
A licensed generic contains the same active medicine as its branded equivalent and is held to the same regulatory standards, usually at a lower price. Branded and generic versions of the same molecule can both be prescribed; some people prefer the branded product. Your prescriber can advise.
Can I switch from one to another?
People do switch — for cost, supply, side effects or effectiveness — but it should be done with a prescriber's guidance, not by stopping and starting on your own. Our switch information can help you compare options if you're considering a change.

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